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目的 调查浙江地区胃癌病人胃组织中EB病毒的感染情况。方法 用PCR方法对26例胃癌组织和15例非胃癌胃组织标本进行EBV -DNA测定。 结果 26例胃癌病人胃癌组织EBV -DNA阳性19例 (73.1 % ) ;其中9例分化型腺癌EBV -DNA阳性5(55.6 % ) ,12例低分化腺癌阳性11例 (91.7 % ) ;5例粘液、印戒细胞癌阳性3例 (60 % )。对照组15例胃组织阳性6例 (40% ) ,( χ2=4.37,p<0.05)。结论 本研究提示 ,浙江地区胃癌病人胃癌组织存在较高的EB病毒感染 ,EB病毒可能参与了胃癌的发生
Objective To investigate the infection status of Epstein-Barr virus (EBV) in stomach tissue of gastric cancer patients in Zhejiang province. Methods The EBV-DNA of 26 cases of gastric cancer and 15 cases of non-gastric cancer tissues were detected by PCR. Results EBV-DNA was positive in 19 gastric cancer tissues (73.1%) in 26 gastric cancer patients. EBV-DNA positive was 5 (55.6%) in 9 cases of differentiated adenocarcinoma and 11 cases (91.7%) in 12 cases of poorly differentiated adenocarcinoma. Cases of mucus, signet ring cell carcinoma positive in 3 cases (60%). In the control group, 15 cases of gastric tissue were positive in 6 cases (40%) (χ2 = 4.37, p <0.05). Conclusions This study suggests that there is a high level of Epstein-Barr virus infection in gastric cancer patients in Zhejiang province and Epstein-Barr virus may be involved in the occurrence of gastric cancer