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5-氟尿嘧啶(fluorouracil)作为抗代谢药已用于眼科手术中。临床证实在玻璃体切割术后应用它可以抑制增殖性玻璃体视网膜病变;在抗青光眼手术后可以抑制滤过道处的疤痕形成。同时也注意到它对眼的潜在性毒性作用,如引起角膜上皮缺损、混浊、新生血管的形成。为弄清其对角膜内皮的影响,作者观察了5-氟尿嘧啶对离体羊角膜内皮的影响,用生理
5-fluorouracil has been used as an antimetabolite in ophthalmic surgery. It has been clinically proven that it can inhibit proliferative vitreoretinopathy after vitrectomy and can inhibit scarring at the filter tract after anti-glaucoma surgery. It also notices its potential toxic effects on the eye, such as corneal epithelial defects, haze, and neovascularization. To clarify its impact on the corneal endothelium, the authors observed the effects of 5-fluorouracil on isolated corneal endothelium, with physiology