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目的:观察比较埃索美拉唑四联疗法与兰索拉唑四联疗法治疗HP相关性溃疡效果。方法:我院消化内科初诊的消化性溃疡且HP检测阳性患者126例。随机分为观察组与对照组,观察比较两组患者临床症状改善情况、HP根除情况、溃疡愈合情况。结果:治疗周期结束后4周观察组患者HP根除率97.06%,明显高于对照组的88.26%(p<0.05)。治疗周期结束后观察组溃疡总有效率91.18%,明显高于对照组(p<0.05)。结论:应用以埃索美拉唑为基础的四联疗法治疗HP相关性消化性溃疡在临床症状改善、HP根除及溃疡愈合方面均优于兰索拉唑,值得临床推荐。
Objective: To compare the efficacy of esomeprazole quadruple therapy and lansoprazole quadruple therapy in the treatment of HP-related ulcer. Methods: 126 cases of peptic ulcer newly diagnosed in our hospital and HP positive test. The patients were randomly divided into observation group and control group. Clinical symptoms, HP eradication and ulcer healing were observed and compared between the two groups. Results: HP eradication rate in the observation group was 97.06% 4 weeks after the end of the treatment period, which was significantly higher than that of the control group (88.26%, p <0.05). After the end of the treatment period, the total effective rate of the ulcer in the observation group was 91.18%, which was significantly higher than that in the control group (p <0.05). Conclusions: The application of esomeprazole-based quadruple therapy in the treatment of HP-associated peptic ulcer is superior to lansoprazole in clinical symptoms, HP eradication and ulcer healing, which is worthy of clinical recommendation.