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目的:探究泮托拉唑与奥美拉唑治疗老年消化性溃疡的临床疗效。方法:在本次研究中选择2014年8月-2015年7月我院收治的91例老年消化性溃疡患者为研究对象,按照治疗方式的差异性,将其分为甲组和乙组,甲组45例患者,乙组46例患者。甲组采用泮托拉唑进行治疗,乙组采用奥美拉唑进行治疗,对临床治疗效果进行对比分析。结果:乙组的有效人数有41例,治疗总有效率为91.1%,乙组的有效人数有39例,治疗总有效率为84.7%,两组比较结果差异性明显,具有统计学意义(p>0.05)。甲组不良反应的患者有3例,不良反应率为6.7%,乙组的不良反应患者有4例,不良反应率为8.7%,两组不良反应率无明显差异性,不具有统计学意义(P>0.05)。结论:泮托拉唑与奥美拉唑在治疗老年消化性溃疡中效果比较明显,其中泮托拉唑不影响肝细胞色素酶的活性,适用范围更广。
Objective: To investigate the clinical efficacy of pantoprazole and omeprazole in the treatment of senile peptic ulcer. Methods: In this study, 91 elderly patients with peptic ulcer admitted from August 2014 to July 2015 in our hospital were selected as the research objects. According to the difference of treatment methods, they were divided into group A and group B Group 45 patients, Group B 46 patients. Group A was treated with pantoprazole, Group B was treated with omeprazole, and the clinical effects were compared. Results: The effective number of patients in group B was 41, the total effective rate was 91.1%, the effective number of patients in group B was 39 and the total effective rate was 84.7%. The difference between the two groups was statistically significant (p > 0.05). A group of patients with adverse reactions in 3 cases, the adverse reaction rate was 6.7%, B patients with adverse reactions in 4 cases, the adverse reaction rate was 8.7%, the two groups had no significant difference in adverse reactions, not statistically significant ( P> 0.05). Conclusion: The effects of pantoprazole and omeprazole in the treatment of peptic ulcer in the elderly are more obvious. Among them, pantoprazole does not affect the activity of hepatocyte.