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64例符合诊断标准的糖尿病肾病患者随机分为两组;A组为观察组,予胰岛素强化治疗,B组为对照组,予口服降糖药控制血糖。两组于治疗前及治疗第2、4周时检测24h尿白蛋白排泄率(AER)、肾功能(BUN、Cr)、空服血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)。结果:A组AER水平2、4周时明显低于B组同期水平(P<0.05),较治疗前有明显下降(P<0.05)。B组AER水平2、4周时较治疗前无明显变化(P>0.05)结论胰岛素强化治疗对减少早期糖尿病肾病患者尿微量白蛋白和保护肾功能有良好的效果。
Sixty-four patients with diabetic nephropathy who met the diagnostic criteria were randomly divided into two groups. Group A was treated with intensive insulin treatment, while group B was the control group. Oral hypoglycemic agents were used to control blood glucose. The levels of urinary albumin excretion (AER), renal function (BUN, Cr), blood glucose (FBG), 2h postprandial blood glucose (PBG), glycosylated hemoglobin HbA1c). Results: The levels of AER in group A were significantly lower than those in group B at 2 and 4 weeks (P <0.05), significantly lower than those before treatment (P <0.05). There was no significant difference in AER between the two groups at 2 and 4 weeks after treatment (P> 0.05). Conclusion Intensive insulin therapy has a good effect on reducing urinary albumin and protecting renal function in patients with early diabetic nephropathy.