妊娠期高血压疾病的病理特征是滋养细胞对子宫内膜浸入过浅和子宫螺旋动脉重塑障碍。缺氧诱导因子-1(HIF-1)在滋养细胞浸润、胎盘血管重塑中起关键作用。近年发现与之相关的因子如:转化生长因子(TGF)、血管内皮生长因子(VEGF)、诱导型一氧化氮合酶(iNOS)、葡萄糖转运因子-1(GULT-1),Bcl-2家族中的BNIP3等,在妊娠期高血压疾病中异常表达,并与HIF-1的表达有相关性。研究HIF-1及其相关因子在妊娠期高血压疾病发生、发展中的作用,期望为妊娠期高血压疾病的治疗寻找新靶点。 Pathologic features of hypertensive disorders during pregnancy are trophoblastic cells that are too submerged in the endometrium and dysplasia of the uterine spiral artery. Hypoxia-inducible factor-1 (HIF-1) plays a key role in trophoblast invasion and placental vascular remodeling. In recent years, related factors such as transforming growth factor (TGF), vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), glucose transporter-1 (GULT-1) In BNIP3 and so on, abnormal expression in gestational hypertension, and with the correlation of HIF-1 expression. To study the role of HIF-1 and its related factors in the occurrence and development of hypertensive disorder complicating pregnancy, and to find a new target for the treatment of hypertensive disorder complicating pregnancy.