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目的探讨P物质及血管活性肠肽在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)舌根平面阻塞中的意义。方法通过免疫组织化学染色对49例OSAHS患者的舌根组织的P物质及血管活性肠肽的表达进行分析。结果OSAHS患者舌根组织中的粘膜下层、小血管周围、腺泡及腺导管周围均有多量P物质及血管活性肠肽表达。P物质在有舌根肥厚组阳性表达率为80.6%(25/31),在无舌根肥厚组的阳性表达率为33.3%(6/18),经统计学处理χ2=10.97,P=0.0009;血管活性肠肽在有舌根肥厚组的阳性表达率为90.3%(28/31),在无舌根肥厚组的阳性表达率为55.6%(10/18),χ2=12.2969,P=0.0005,差异有统计学意义。结论OSAHS患者舌根组织中有多量P物质及血管活性肠肽表达,它们可引起局部组织肿胀并参与神经源性炎症,进而引起舌根肥厚和塌陷。
Objective To investigate the significance of substance P and vasoactive intestinal peptide in the tongue base obstruction of obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods The expression of substance P and vasoactive intestinal peptide in tongue base of 49 patients with OSAHS were analyzed by immunohistochemical staining. Results There was significant amount of substance P and vasoactive intestinal peptide in the submucosa, small blood vessels, acinar and glandular ducts in the tongue root of OSAHS patients. The positive expression rate of substance P in tongue hypertrophy group was 80.6% (25/31), in tongueless hypertrophy group, the positive expression rate of substance P was 33.3% (6/18), the statistical treatment χ2 = 10.97, P = 0.0009; The positive expression rate of active intestinal peptide in tongue hypertrophy group was 90.3% (28/31), no tongue hypertrophy group was 55.6% (10/18), χ2 = 12.2969, P = 0.0005, the difference was statistically significant Significance of learning. Conclusions There is a large amount of substance P and vasoactive intestinal peptide in the tongue base of patients with OSAHS. They can cause local tissue swelling and participate in neurogenic inflammation, leading to hypertrophy and collapse of tongue base.