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①目的 探讨多药耐药基因在脑胶质瘤组织中的表达及其意义。②方法 采用免疫组化Ｓ－Ｐ法，检测了３８ 例脑胶质瘤组织中多药耐药基因Ｐ１７０ 蛋白的表达。③结果 ３８ 例脑胶质瘤组织中Ｐ１７０ 蛋白的阳性表达率为６５．７％ ，与正常脑组织（表达率为０）比较差异有显著性（Ｐ＝ ０）。Ｐ１７０在Ⅰ～Ⅳ级脑胶质瘤的阳性表达率分别为０，５３．３％ ，７０．６％ ，１００．０％ ，其中Ⅰ级与Ⅲ，Ⅳ级间差异有显著性（Ｐ＝ ０．０１８，０．００３）， 其余各组间差异无显著性。Ｐ１７０ 的异常表达与脑胶质瘤的病理级别呈正相关（ｒｓ＝ ０．８８２，Ｐ＜ ０．０５）。④结论 检测脑胶质瘤Ｐ１７０ 表达水平对判断化疗效果及预后有一定意义。
Objective To investigate the expression and significance of multidrug resistance gene in glioma tissues. Methods The immunohistochemical S-P method was used to detect the expression of multidrug resistance gene P170 in 38 glioma tissues. ③ Results The positive rate of P170 protein in 38 glioma tissues was 65.7%, which was significantly different from that in normal brain tissues (P = 0). The positive expression rates of P170 in Grade Ⅰ ~ Ⅳ gliomas were 0, 53.3%, 70.6% and 100.0%, respectively. There was significant difference between Grade Ⅰ and Grade Ⅲ and Grade Ⅳ (P = 0 .018,0.003), no significant difference between the other groups. The abnormal expression of P170 was positively correlated with the pathological grade of glioma (rs = 0.882, P <0.05). ④ Conclusion Detection of glioma P170 expression level to determine the effect of chemotherapy and prognosis of some significance.