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目的：大样本探讨ＣａｔｈｅｐｓｉｎＤ、ｎｍ２３作为乳腺浸润性导管癌术后预后判断指标的可信性。方法：应用免疫组织化学ＳＰ法检测ＣａｔｈｅｐｓｉｎＤ、ｎｍ２３在乳腺浸润性导管癌中的表达。结果：９４例乳腺浸润性导管癌间质细胞ＣａｔｈｅｐｓｉｎＤ的阳性表达与局部淋巴结转移及远处转移呈正相关，与生存时间呈负相关（Ｐ＜００１）。癌细胞ｎｍ２３阳性表达与局部淋巴结转移和远处转移呈负相关，与生存时间呈正相关（Ｐ＜００１）。结论：ＣａｔｈｅｐｓｉｎＤ，ｎｍ２３可作为乳腺浸润性导管癌术后转移和远期生存率的重要预测指标。
Objective: To investigate the reliability of Cathepsin D and nm23 as predictors of prognosis of invasive ductal carcinoma of the breast in large samples. Methods: The expression of CathepsinD and nm23 in breast invasive ductal carcinoma was detected by immunohistochemical SP method. RESULTS: The positive expression of CathepsinD in 94 infiltrating ductal carcinomas was positively correlated with regional lymph node metastasis and distant metastasis, and negatively correlated with survival time (P<001). The positive expression of nm23 in cancer cells was negatively correlated with regional lymph node metastasis and distant metastasis, and positively correlated with survival time (P<001). Conclusion: Cathepsin D and nm23 can be used as important predictors of metastasis and long-term survival of breast invasive ductal carcinoma.