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上皮间质转化(EMT)是指上皮细胞在特定的生理或病理条件下转化为具有间质表型细胞的生物学过程。EMT在胚胎发育、组织再生、癌症转移和器官纤维化疾病中发挥重要作用。根据EMT发生的不同生物学环境,EMT可分为Ⅰ、Ⅱ、Ⅲ型,其中II型EMT在疾病器官纤维化中发挥重要作用。肾间质纤维化(RIF)是DN的主要病理特征,EMT在DN中RIF发生发展中的相关分子机制研究,将为指导临床干预RIF过程中EMT的进展,逆转纤维化进程提供可能。
Epithelial-mesenchymal transition (EMT) refers to the biological processes by which epithelial cells transform into mesenchymal cells under specific physiological or pathological conditions. EMT plays an important role in embryonic development, tissue regeneration, cancer metastasis and organ fibrosis. According to the different biological environment EMT occurs, EMT can be divided into Ⅰ, Ⅱ, Ⅲ type, in which type II EMT play an important role in the disease organ fibrosis. Renal interstitial fibrosis (RIF) is the main pathological feature of DN. The related molecular mechanism of RIF in DN will provide a possibility for reversing the progress of EMT in clinical intervention of RIF.