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目的探讨羚羊角胶囊联合丙戊酸钠治疗外伤后癫痫的临床疗效。方法选取2015年2月—2016年10月在天津医科大学总医院滨海医院进行治疗的外伤后癫痫患者78例,随机分成对照组(39例)和治疗组(39例)。对照组口服丙戊酸钠片,15~20 mg/(kg·d),3次/d。治疗组在对照组基础上口服羚羊角胶囊,0.6 g/次,1次/d。两组经过4个月治疗后进行效果评价。评价治疗后两组患者临床疗效,同时比较治疗前后两组血清学指标、睡眠质量改善情况和癫痫发作频率。结果治疗后,对照组和治疗组的总有效率分别为79.49%和94.87%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清白细胞介素-6(IL-6)、神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)和S100β水平均显著降低(P<0.05);且治疗组血清IL-6、NSE、BDNF和S100β水平明显好于对照组(P<0.05)。治疗后,两组患者AIS评分、ESS评分和PSQI评分均明显下降(P<0.05);且治疗组AIS评分、ESS评分和PSQI评分明显低于对照组(P<0.05)。治疗后,两组癫痫发作频率均比治疗前明显降低(P<0.05);且治疗组患者癫痫发作频率明显低于对照组(P<0.05)。结论羚羊角胶囊联合丙戊酸钠片治疗外伤后癫痫效果明确,可有效改善患者临床症状及促进神经功能恢复,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Antelope angle capsule combined with sodium valproate in the treatment of posttraumatic epilepsy. Methods Totally 78 patients with traumatic epilepsy who were treated in Binhai Hospital of Tianjin Medical University from February 2015 to October 2016 were randomly divided into control group (39 cases) and treatment group (39 cases). The control group oral sodium valproate tablets, 15 ~ 20 mg / (kg · d), 3 times / d. The treatment group on the basis of the control group oral antelope angle capsule, 0.6 g / time, 1 time / d. Two groups after 4 months of treatment effect evaluation. The clinical efficacy of the two groups after treatment was evaluated. Serum parameters, sleep quality and epileptic seizure frequency were compared between the two groups before and after treatment. Results After treatment, the total effective rates of the control group and the treatment group were 79.49% and 94.87%, respectively. There was significant difference between the two groups (P <0.05). After treatment, the levels of serum IL - 6, NSE, BDNF and S100β were significantly decreased in both groups (P <0.05). The levels of IL-6, NSE, BDNF and S100β in the treatment group were significantly better than those in the control group (P <0.05). After treatment, AIS score, ESS score and PSQI score decreased significantly in both groups (P <0.05). The scores of AIS, ESS and PSQI in the treatment group were significantly lower than those in the control group (P <0.05). After treatment, the seizure frequency of both groups was significantly lower than that before treatment (P <0.05); and the frequency of seizure in the treatment group was significantly lower than that of the control group (P <0.05). Conclusion Antelope angle capsules combined with sodium valproate tablets in the treatment of posttraumatic epilepsy clear effect, which can effectively improve the clinical symptoms and promote neurological recovery, has some clinical application value.