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目的观察联合应用大剂量纳洛酮治疗重型脑外伤的临床疗效。方法 68例重型脑外伤患者,随机分为观察组与对照组,各34例。两组均根据具体病情予以颅内血肿清除、去骨瓣减压、脱水降颅压、营养神经、调节水电解质酸碱失衡等基础治疗,观察组予以大剂量纳洛酮治疗,对照组予以胞二磷胆碱治疗。观察两组患者意识觉醒时间和预后的差异评估临床疗效。结果观察组治疗10 d后显效率76.47%高于对照组的52.94%,差异具有统计学意义(P<0.05)。观察组治疗3个月后恢复良好率73.53%高于对照组的47.06%,差异具有统计学意义(P<0.05)。结论在治疗重型脑外伤时及早、大量应用纳洛酮能缩短患者意识觉醒时间,取得较好的预后,降低病残率。
Objective To observe the clinical effect of combined high-dose naloxone on severe traumatic brain injury. Methods Sixty-eight patients with severe traumatic brain injury were randomly divided into observation group and control group, with 34 cases in each group. Both groups were given intracranial hematoma removal, decompressive craniectomy, dehydration intracranial pressure, nutrient nerves, regulating the acid-base imbalance of aqueous electrolyte and other basic treatment. The observation group was treated with high-dose naloxone, and the control group was given cells Diphosphocholine treatment. The difference of consciousness awakening time and prognosis between the two groups was observed to evaluate the clinical effect. Results The effective rate of observation group after treatment for 10 days was 76.47% higher than that of control group (52.94%), the difference was statistically significant (P <0.05). After 3 months of treatment, the recovery rate of observation group was 73.53% higher than that of control group (47.06%), the difference was statistically significant (P <0.05). Conclusion Early treatment of severe traumatic brain injury, naloxone used in large numbers can shorten the consciousness of patients awakening time, get a better prognosis and reduce morbidity.