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目的探讨乳腺淋巴瘤的临床特征、诊断及治疗方法。方法回顾性分析了12例乳腺淋巴瘤患者的临床资料。结果发病时双侧受累1例,单侧受累11例。肿瘤平均直径4.9cm。11例为弥漫大B细胞淋巴瘤,1例为黏膜相关淋巴瘤。6例行手术治疗,术后与6例粗针穿刺明确诊断的非手术患者均行化疗为主的综合治疗,多选用基于CHOP(环磷酰胺+阿霉素+长春新碱+泼尼松)的化疗方案,非生发中心源性CD20+淋巴瘤患者加用利妥昔单抗。结论粗针穿刺活检有助于明确乳腺淋巴瘤的诊断。手术有助于诊断,但治疗意义尚不肯定。应根据患者具体情况采用化疗为主的综合治疗。
Objective To investigate the clinical features, diagnosis and treatment of breast lymphoma. Methods The clinical data of 12 patients with breast lymphoma were retrospectively analyzed. Results The incidence of bilateral involvement in 1 case, unilateral involvement in 11 cases. The average tumor diameter 4.9cm. Eleven cases were diffuse large B-cell lymphoma and one case was mucosal-associated lymphoma. 6 patients underwent surgical treatment, postoperative and 6 cases of needle puncture clear diagnosis of non-surgical patients underwent chemotherapy-based comprehensive treatment, multiple choice based on CHOP (cyclophosphamide + doxorubicin + vincristine + prednisone) Chemotherapy regimen plus rituximab in patients with non-germinal center-derived CD20 + lymphoma. Conclusion The needle biopsy can help confirm the diagnosis of breast lymphoma. Surgery helps diagnosis, but the therapeutic significance is not yet sure. Should be based on the specific circumstances of patients with chemotherapy-based comprehensive treatment.