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用30％Ⅲ度烧伤大鼠模型，观察了伤后血浆、肝脏ET含量变化及ET受体拮抗剂PD145065对肝脏损害的影响，发现大鼠烧伤后血浆及肝组织ET明显增加，且与肝血流量下降呈显著负相关，PD145065可增加肝血流量，恢复肝组织SOD活性、ATP、ADP的含量，减少MDA、AMP含量，减轻肝组织水肿。表明内源性ET的增加参与了烧伤早期肝脏损害的发生。
The effects of ET-antagonist PD145065 on liver damage were observed by using 30% Ⅲ degree burn rat model. The ET and plasma ET levels were significantly increased after burn in rats, PD145065 could increase hepatic blood flow, restore SOD activity, ATP and ADP in liver tissue, decrease MDA and AMP content, and reduce liver edema. This indicates that the increase of endogenous ET is involved in the occurrence of liver damage in the early stage of burn.