作者描述了经骨髓移植的29例患者中7例肝脏发生了静脉闭塞性疾病,而该病可能是人类对移植物复杂反应的一个部分。29例中,1例患者系18岁男性,患急性粒细胞性白血病,移植后病愈5年多,健康良好,余28例死亡,22例进行了尸检。25例患白血病,3例再生障碍性贫血,1例弥漫性膀胱癌,所有患者均接受多次输血。29例共进行了34次移植。7例患者尽管骨髓移植成功,但均死亡,肝功能衰竭是4例死亡的主要原因,另3例的死亡亦与肝功能衰竭有关。7例肝静脉阻塞性疾病,主要累及皮肤和胃肠道,皮肤受累的诊断是根据乳头内淋巴样浸润和皮肤上毛细血管周围淋巴样聚集,常伴内皮细胞肿胀和血管周围水肿。不同 The authors described venous occlusive disease in seven of the 29 patients who underwent bone marrow transplantation, a disease that may be part of a complex human response to a graft. Of the 29 patients, one patient was an 18-year-old man with acute myeloid leukemia and had recovered for more than 5 years after transplantation. He was well-nourished, with 28 more dead and 22 autopsied. 25 cases of leukemia, 3 cases of aplastic anemia, 1 case of diffuse bladder cancer, all patients received multiple transfusions. 29 cases carried out a total of 34 transplants. All 7 patients died despite successful bone marrow transplantation. Liver failure was the main cause of death in 4 patients. The other 3 deaths were also related to liver failure. Seven cases of hepatic veno-occlusive disease mainly involving the skin and gastrointestinal tract. The diagnosis of skin involvement is based on lymph infiltration within the nipple and lymphoid aggregation around the capillaries on the skin, often accompanied by endothelial cell swelling and perivascular edema. different