【摘 要】
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The situation of tuberculosis and M. tuberculosis (MTB) drug resistance is severe in China. Among the MTB isolates, 27.8% were resistant to one primary antitub
【机 构】
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Tuberculosis Research Laboratory, Tuberculosis Center, 309th Hospital of PLA, Beijing 100091, China“
论文部分内容阅读
The situation of tuberculosis and M. tuberculosis (MTB) drug resistance is severe in China. Among the MTB isolates, 27.8% were resistant to one primary antituberculosis drug at least. Isoniazid (INH) is one of the first-line anti-TB drugs. The rates of primary resistance and acquired resistance to INH were 11.0% and 31.0%, respectively.1 MTB strains resistance to INH is mainly caused by the alterations in several genes encoding the molecular targets as follows: catalase peroxidase (katG), the enoyl-acyl carrier protein reductase (inhA), the alkyl hydroperoxide reductase (ahpC), beta-ketoacyl-acyl carrier protein synthase (kasA), and NADH dehydrogenase (ndh).2-4 However, the mutations of katG and inhA promoter region, especially in codon 315 of katG, were found in the majority of INH-resistant clinical isolates.
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