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机体在防御微生物感染与维持自身耐受之间保持着完美的平衡,而B7-CD28家族信号通路可以精确调节该平衡所需的刺激和抑制信号[1,2]。B7-CD28家族有许多能削弱T细胞应答并促进T细胞耐受的抑制性信号通路,其中近年发现的PD-1-PD-L通路由于独特的抑制功能引人瞩目,被认为是影响自身
The body maintains a perfect balance between defense against microbial infection and maintenance of self-tolerance, whereas the B7-CD28 family of signaling pathways precisely regulate the stimulatory and inhibitory signals required for this balance [1,2]. The B7-CD28 family has a number of inhibitory signaling pathways that attenuate T cell responses and promote T cell tolerance. The PD-1-PD-L pathway found in recent years has drawn attention due to its unique inhibitory function and is believed to affect itself