运动神经元病(motor neuron d isease,MND)是一组选择性侵犯脊髓前角细胞、脑干后组运动神经元、皮质锥体细胞及锥体束的慢性进行性变性疾病[1]。患者一般在症状出现后3~5年内死亡,迄今为止尚无有效的方法治愈或阻止其病情发展。因此支持性治疗越来越受到重视,一些临床研究发现 Motor neuron d isease (MND) is a group of chronic progressive degenerative diseases that selectively invade spinal cord anterior horn cells, motor neurons in the brainstem group, cortical pyramidal cells, and pyramidal tract [1]. Patients usually die within 3 to 5 years after the onset of symptoms, and so far no effective method has been found to cure or prevent their progression. Therefore, more and more attention to supportive treatment, some clinical studies have found