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目的:探讨膳食大豆食物摄入与全肿瘤死亡风险的关系。方法:利用上海男性健康队列(2002—2013年)和上海女性健康队列(1997—2013年)的调查资料,采用食物频率调查表收集膳食大豆食物摄入的相关信息。使用COX比例风险模型调整潜在混杂因素,估算膳食大豆食物摄入与全肿瘤死亡的风险比(hazard ratio,HR)及其95%可信区间(95%confidence interval,95%CI)。结果:最终纳入59 857名男性和73 044名女性参与者。上海男性和女性健康队列分别平均随访9.2年和14.7年,确诊2 122例男性和2 580例女性恶性肿瘤死亡病例。以膳食大豆食物摄入量最低四分位组为参考,男女性最高摄入组人群的HR分别为0.99(95%CI:0.87~1.12)和0.96(95%CI:0.85~1.08),提示膳食大豆食物摄入与全肿瘤死亡风险的关联没有统计学意义。进一步的分析结果提示,膳食大豆异黄酮摄入水平与男女性全肿瘤死亡风险也没有关联,相应的HR分别为1.06(95%CI:0.93~1.19)和0.98(95%CI:0.88~1.10)。结论:膳食大豆食物摄入可能与全肿瘤死亡风险的降低没有关联。
Objective: To investigate the relationship between food intake of dietary soybeans and the risk of total tumor death. Methods: Based on the survey data of Shanghai Male Health Cohort (2002-2013) and Shanghai Women’s Health Cohort (1997-2013), the food frequency questionnaire was used to collect the relevant information of dietary soybean food intake. Potential confounders were adjusted using the COX proportional hazard model to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) of dietary soy food intake to total tumor death. Results: 59,857 men and 73,044 female participants were eventually included. The Shanghai male and female health cohorts were followed up for an average of 9.2 years and 14.7 years, respectively, in 2 122 men and 2 580 deaths from malignant tumors in women. Taking the lowest quartile of dietary soybeans as the reference, the HRs of the highest male and female intake groups were 0.99 (95% CI: 0.87-1.12) and 0.96 (95% CI: 0.85-1.08), respectively, suggesting that the diet The association between soy food intake and total tumor death risk was not statistically significant. Further analysis showed that dietary soy isoflavone intake was also unrelated to the risk of total cancer death in men and women, with corresponding HRs of 1.06 (95% CI: 0.93-1.19) and 0.98 (95% CI: 0.88-1.10) . Conclusion: Food intake of dietary soybeans may not be associated with a reduction in the risk of total tumor death.