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1973年GuilleminR发现在下丘脑中具有独特效应的由十四个氨基酸所组成环状肽类化合物因能抑制垂体生长激素分泌被称生长激素释放抑制素（Somatostatin），瑞士Sandoz药厂研制了人工合成的八肽生长抑素——善得定（奥曲肽，Sandostatin），并成功地应用于门脉高压食管胃底静脉曲
GuilleminR found in 1973 the unique hypothalamus has a unique effect of the cyclic peptide composed of fourteen amino acids due to inhibition of pituitary growth hormone secretion known as somatostatin (Somatostatin), the Swiss Sandoz Pharmaceutical Factory developed a synthetic Octapeptide Somatostatin - good set of Ding (octreotide, Sandostatin), and successfully used in portal hypertension esophageal varices