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LH-RH是丘脑下部所释放的一种肽类激素。它的主要生理功能是通过垂体门脉系统刺激腺垂体合成和分泌促性腺激素,对维持性功能起重要作用。但是,Corbin等发现,高剂量的LH-RH或LH-BH-A对生殖功能有明显抑制作用:每天给妊娠大鼠注射1毫克LH-RH,连续7天(D_1-D_7),可使100%的受试动物终止妊娠。Lin等进一步肯定了上述实验结果。刘以训等的工作亦证明:着床前给妊娠大鼠每天注射200微克LH-RH-A,连续注射3天(D_3-D_5),使18只受试动物全部终止妊娠。因此,高剂量的LH-RH或类似物对生殖
LH-RH is a peptide hormone released by the hypothalamus. Its main physiological function is to stimulate the pituitary gland synthesis and secretion of gonadotropins through the pituitary portal system, play an important role in the maintenance of sexual function. However, Corbin et al found that high doses of LH-RH or LH-BH-A significantly inhibited reproductive function. Pregnant rats were injected with 1 mg LH-RH daily for 7 days (D_1-D_7) % Of the animals tested terminated their pregnancy. Lin further confirmed the above experimental results. The work of Liu Yixun et al also proved that pregnant rats were injected with 200 μg of LH-RH-A daily for 3 days (D_3-D_5), and 18 animals were terminated. Therefore, high doses of LH-RH or analogs reproduce