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目的比较常规体外受精(in vitro fertilization,IVF)失败后6h和22h进行挽救性卵胞浆内单精子显微注射(intra-cytoplasmic sperm injection,ICSI)的效果。方法 65个IVF受精失败的周期中50个周期于受精后6h,15个周期于受精后22h进行挽救性ICSI,对受精率、卵裂率、胚胎质量、种植率和妊娠率进行比较。结果 6h组的受精率显著高于22h组(77.1%vs47.5%),差异有统计学意义(P<0.05);6h组的卵裂率显著高于22h组(97.1%vs68.3%),差异有统计学意义(P<0.05);6h组的临床妊娠率44.0%,18例单胎4例双胎,22h组无1例妊娠(P<0.05)。结论受精6h后进行挽救性ICSI可获得更好的受精率、种植率和临床妊娠率。
Objective To compare the effects of salvage intracytoplasmic sperm injection (ICSI) 6h and 22h after in vitro fertilization (IVF) failure. Methods Sixty-five cycles of IVF fertilization failure were performed at 50 cycles of salvage ICSI at 6 h and 15 cycles after fertilization at 22 h after fertilization. Fertilization rate, cleavage rate, embryo quality, implantation rate and pregnancy rate were compared. Results The fertilization rate in 6h group was significantly higher than that in 22h group (77.1% vs 47.5%, P <0.05). The cleavage rate in 6h group was significantly higher than that in 22h group (97.1% vs 68.3%) , The difference was statistically significant (P <0.05). The clinical pregnancy rate was 44.0% in 6h group, 4 in 18 singletons, and 1 in 22h group (P <0.05). Conclusions Salvage ICSI after fertilization for 6 hours results in better fertilization rate, implantation rate and clinical pregnancy rate.