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肿瘤细胞的内在和(或)获得性多药耐药是导致肿瘤患者化疗失败的主要原因,寻求个体化化疗方案,是目前临床研究中的热点和难点。对肺癌细胞进行体外培养、药物敏感性试验和检测耐药基因的表达将为临床化疗提供客观的依据。现综述肺癌细胞的体外培养、药物敏感性及耐药基因检测方面的研究进展。
The intrinsic and / or acquired multidrug resistance of tumor cells is the main reason for the failure of chemotherapy in cancer patients. To seek personalized chemotherapy regimens is the hot and difficult point in current clinical research. In vitro culture of lung cancer cells, drug susceptibility testing and detection of drug resistance gene expression will provide an objective basis for clinical chemotherapy. The research progress of lung cancer cells in vitro culture, drug sensitivity and drug resistance gene detection are reviewed.