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目的探讨利奈唑胺联合广谱抗菌药物治疗老年意识障碍并吸入性肺炎的临床疗效及其对患者血液系统的影响。方法选取2013年2月—2014年10月高安市人民医院收治的64例老年意识障碍并吸入性肺炎患者,随机分为观察组和对照组,各32例。两组均给予广谱抗菌药物治疗,在此基础上,观察组患者给予利奈唑胺治疗,对照组患者给予替考拉宁治疗,观察两组患者临床疗效及血常规异常情况。结果观察组患者总有效率为93.75%,高于对照组的84.38%,差异有统计学意义(P<0.05);观察组32例患者中出现3例(9.38%)血小板计数减少,1例(3.13%)血红蛋白水平降低,血液系统不良反应发生率为12.50%。结论利奈唑胺联合广谱抗菌药物治疗老年意识障碍并吸入性肺炎的疗效显著,但易发生血液系统不良反应,应用该药治疗时应密切监测血常规变化并给予对症处理。
Objective To investigate the clinical efficacy of linezolid and broad-spectrum antimicrobial agents in the treatment of senile dementia with aspiration pneumonia and its effect on the blood system of patients. Methods Sixty-four elderly patients with cognitive impairment and aspiration pneumonia admitted from February 2013 to October 2014 in Gao’an Municipal People’s Hospital were randomly divided into observation group and control group, with 32 cases in each group. Both groups were treated with broad-spectrum antimicrobial drugs. On this basis, the patients in the observation group were treated with linezolid, the patients in the control group were treated with teicoplanin, and the clinical efficacy and abnormalities of blood were observed in both groups. Results The total effective rate in the observation group was 93.75%, which was higher than that in the control group (84.38%), the difference was statistically significant (P <0.05); in the observation group of 32 patients, the platelet count decreased in 3 cases (9.38% 3.13%) hemoglobin level decreased, the incidence of adverse reactions in the blood system was 12.50%. Conclusion Linezolid and broad-spectrum antimicrobial agents have significant therapeutic effect on senile dementia with aspiration pneumonia, but are prone to adverse reactions in the blood system. The blood routine changes should be closely monitored and treated symptomatically.