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随机应用腺苷蛋氨酸与门冬氨酸钾镁治疗慢性病毒性肝炎各 30例。治疗组腺苷蛋氨酸每日 1g ,静滴 2 8天 ,继口服腺苷蛋氨酸 0 .5 g,每日 2次 2 8天 ;对照组门冬氨酸钾镁每日 30ml,静滴 2 8天 ,继口服门冬氨酸钾镁 (脉安定 ) 0 .2 g,每日 2次 2 8天。结果显示 ,治疗组有效率达 83 .33% ,而对照组有效率为 46 .6 7% ,两组比较P <0 .0 0 5。治疗组至疗程结束时 ,总胆红素、结合胆红素和丙氨酸转氨酶 (ALT)分别下降至治疗前基础值的 31.81%、32 .83 %和 36 .0 0 % ,均较对照组下降明显 (P <0 .0 5 )。治疗组不良反应发生率为 10 % ,但均轻微 ,不需处理。腺苷蛋氨酸治疗慢性病毒性肝炎临床疗效较满意 ,值得临床应用。
30 cases of chronic viral hepatitis were treated with adenosylmethionine and potassium magnesium aspartate. Treatment group adenosine methionine daily 1g, intravenous 28 days, following oral administration of adenosine methionine 0 .5 g, 2 times daily 2 8 days; control group potassium aspartate daily 30ml, intravenous 28 days , Following oral administration of potassium magnesium aspartate (pulse stability) 0 .2 g, 2 times a day 2 8 days. The results showed that the effective rate of the treatment group was 83.33%, while the control group was 46.66%, P <0.05. The treatment group to the end of treatment, total bilirubin, conjugated bilirubin and alanine aminotransferase (ALT) decreased to 31.81%, 32.83% and 36.0% before treatment, respectively, compared with the control group Decreased significantly (P <0.05). The incidence of adverse reactions in the treatment group was 10%, but both were mild and did not need treatment. Adenosine methionine treatment of chronic viral hepatitis is more satisfactory clinical efficacy, it is worth clinical application.