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目的探讨羟基脲(hydroxyurea,HU)联合化疗治疗高白细胞急性白血病的疗效。方法将30例高白细胞急性白血病的患者按随机原则分为观察组和对照组。观察组21例化疗前应用 HU 1.0 g,每天3次,连用3～7 d,同时加用别嘌呤醇200 mg,每天3次;对照组18例单用化疗。结果观察组完全缓解(CR)12例(57.1%),部分缓解(PR)4例(19.0%),未缓解(NR)5例(23.8%),总有效率(CR+PR)76.1%,早期病死2例(9.5%);对照组18例,CR 3例(16.7%),PR 6例(33.3%),NR 9例(50%),总有效率(CR+PR)50%,早期病死4例(22.4%)。2组数据经 x~2检验,疗效差异有显著性意义(P<0.01)。结论羟基脲联合化疗治疗高白细胞急性白血病有显著疗效,值得临床推广与应用。
Objective To investigate the efficacy of hydroxyurea (HU) combined with chemotherapy in the treatment of high leukemia acute leukemia. Methods Thirty patients with high white blood cell acute leukemia were randomly divided into observation group and control group. 21 cases of observation group before the application of HU 1.0 g, 3 times a day, once every 3 to 7 d, plus allopurinol 200 mg, 3 times a day; control group of 18 patients with chemotherapy alone. Results There were 12 cases (57.1%) of complete remission (CR), 4 cases of partial remission (PR), 5 cases of untreated (NR) and 76.1% of total effective rate (CR + PR) 3 cases (16.7%) were CR, 6 cases (33.3%) were CR, 9 cases (50%) were NR, 50% of the total effective rate (CR + PR) Four died (22.4%). Two groups of data by x ~ 2 test, the difference was significant (P <0.01). Conclusion Hydroxyurea in combination with chemotherapy for the treatment of acute leukemia patients has a significant effect, which is worthy of clinical application and promotion.