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用表面活性剂[十二烷基硫酸钠(SLS)、吐温80]处理淀粉有下列两种方法:(1)淀粉加至0.5％的表面活性剂水溶液中,搅拌约6小时,过滤,于50℃干燥,过筛,分析表面活性剂含量;(2)计算量表面活性剂与淀粉混合拌匀,分析表面活性剂含量的均匀性。制成颗粒后SLS和吐温80的含量约0.2％。10％(w/w)木薯淀粉胶浆作为粘合剂,湿制颗粒过筛,用作崩解剂的处理淀粉是药物量的5％。在一些处方中,全部用量均作为颗粒内崩解剂;而在其他处方中一半用于颗粒内,另一半则为颗粒外崩解剂。颗粒于50℃干燥至水分含量约1％,过0.25mm筛,压片。在后面一些处方中制湿粒前掺入一半淀
Surfactants [sodium lauryl sulfate (SLS), Tween 80] are used to treat starch in the following two ways: (1) starch is added to a 0.5% aqueous surfactant solution, stirred for about 6 hours, filtered, 50 ℃ drying, sieving, analysis of surfactant content; (2) Calculate the amount of surfactant mixed with starch and mix, analyze the uniformity of the surfactant content. The content of SLS and Tween 80 after granulation is about 0.2%. 10% (w / w) tapioca starch as a binder, wet granulation through the sieve, the treatment of starch used as a disintegrant is 5% of the amount of the drug. In some formulations, the entire amount is used as the intragranular disintegrant, while in other prescriptions, half is used in the granules and the other half is the extragranular disintegrant. The granules were dried at 50 ° C to a moisture content of about 1%, passed through a 0.25 mm sieve and tabletted. In some of the following prescriptions, wet granulation before incorporation of a half of the lake