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[目的]探讨熊去氧胆酸联合腺苷蛋氨酸对妊娠期肝内胆汁淤积症(IC P)患者肝功能及妊娠结局的影响.[方法]抽取2014年2月至2016年10月本院84例IC P患者,根据治疗方案分为两组,各42例.常规治疗基础上对照组给予熊去氧胆酸治疗,观察组给予熊去氧胆酸+腺苷蛋氨酸治疗.对比两组治疗前后血清总胆汁酸(TBA)、肝功能指标[谷草转氨酶(AST)、丙氨酸转氨酶(ALT)]水平、瘙痒症状(Ribalta)评分、负性情绪[焦虑(HAMA)、抑郁(HAMD)]评分,并统计两组妊娠结局与新生儿Apgar评分.[结果]①血清TBA及肝功能:治疗前,两组血清TBA、AST及ALT水平差异无统计学意义(P>00.5),治疗后,观察组血清TBA、AST及ALT水平均低于对照组,差异有统计学意义(P00.5),治疗后,两组Ribalta评分均有所降低,且观察组低于对照组,差异有统计学意义(P00.5),治疗后,观察组HAMA、HAMD评分低于对照组,差异有统计学意义(P00.5) .After treatment ,the serum levels of TBA ,AST and ALT in the observation group were lower than those in the control group ,the difference was statistically significant (P00.5) .Af-ter treatment ,the Ribalta scores of the two groups were reduced ,and the observation group was lower than the control group ,the difference was statistically significant ( P 00.5) .After treatment ,the scores of HAMA and HAMD in the observation group were lower than those in the control group ,the difference was statistically significant ( P <00.5);④pregnancy outcome and neonatal Apgar score :The rate of cesarean section ,premature delivery and postpartum hemorrhage in the observation group was [285.7% (12/42) ,95.2% (4/42) ,47.6% (8/42) ,(2/42)] ,which were lower than those of the control group [500.0% (21/42) ,261.9% (11/42) ,190.5% (8/42)] ,Apgar score was higher than that of the control group ,the difference was statistically significant ( P 00.5) .[Conclu-sion]Ursodeoxycholic acid combined with methionine treatment given for ICP patients can effectively reduce serum TBA levels ,relieve itching symptoms ,improve liver function and eliminate negative emotions ,and thus help improve pregnancy outcomes .