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目的 通过测定血清高密度脂蛋白3(HDL3)，探讨其血清水平与高血压患者合并颈动脉斑块稳定程度的相关性?方法 纳入明确诊断高血压患者140例作为观察组，根据颈动脉B超提示结果 ，将研究对象分为高血压无斑块组(n=32)?高血压合并稳定斑块组(n=40)?高血压合并易损斑块组(n=68)?选取同期年龄?性别相匹配的80例健康者作对照组，采用免疫比浊法检测血清HDL3水平?应用多因素logistic回归分析HDL3与高血压合并颈动脉粥样硬化斑块稳定程度的关系?结果 高血压患者血清HDL3水平明显高于健康对照组“,”Objective To investigate the relationship between serum high density lipoprotein 3 (HDL3) and the stability of carotid plaque in patients with hypertension. Methods A total of 140 patients with hypertension were enrolled in the observation group. According to the results of carotid ultrasound， the subjects were divided into three groups: hypertension non-plaque group (n=32)， hypertension and stable plaque group (n=40)， hypertension and vulnerable plaque group (n=68). A number of 80 healthy subjects were matched with age and sex as control group. The level of serum HDL3 was detected by immunoturbidimetry. Multivariate logistic regression was used to analyze the correlation between HDL3 and hypertension complicated with carotid atherosclerotic plaque stability. Results The level of serum HDL3 in patients with hypertension was significantly higher than that in the control group (P <0.05). There was significant difference in the level of serum HDL3 among the three subgroups of the observation group. The level of HDL3 in the vulnerable plaque group was significantly lower than that in the control group (P <0.05). Logistic regression analysis showed that serum HDL3 level is an independent risk factor for the formation of unstable atherosclerotic plaque in the carotid artery of hypertensive patients (P <0.05). Conclusion The decrease of serum HDL3 level is a risk factor for unstable carotid atherosclerotic plaque in patients with hypertension.