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目的探讨糖皮质激素(GC)对狼疮性肾炎(LN)患者血清及肾内B淋巴细胞刺激因子(BlyS)的影响。方法用ELISA法和免疫组化法检测LN患者与正常对照者的血清和肾内BlyS的表达水平。结果 LN患者血清及肾内BlyS的表达水平显著高于正常对照者(P<0.001);GC治疗>2周组的LN患者肾内BlyS的表达水平及系统性红斑狼疮疾病活动性指数(SLEDAI)评分较未治疗组显著减少(P分别为0.012和0.005)。结论 GC减轻LN患者疾病活动性的作用可能与其降低肾内BlyS水平有关。
Objective To investigate the effect of glucocorticoid (GC) on serum and renal B lymphocyte stimulator (BlyS) in patients with lupus nephritis (LN). Methods The expression of BlyS in serum and kidney of patients with LN and normal controls were detected by ELISA and immunohistochemistry. Results The expression of BlyS in serum and kidney of patients with LN was significantly higher than that of normal controls (P <0.001). The expression of BlyS in kidney and the activity index of systemic lupus erythematosus (SLEDAI) Scores were significantly lower than those in the untreated group (P = 0.012 and 0.005, respectively). Conclusions The role of GC in reducing the disease activity of patients with LN may be related to reducing the level of BlyS in the kidney.