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目的:探讨胱抑素C(CytC)、同型半胱氨酸(t-Hcy)、B型脑钠肽(BNP)、C反应蛋白(hs-CRP)、β2-微球蛋白(β2-MG)与老年2型糖尿病肾病(DN)的关系。方法:测定单纯2型糖尿病组(NDN)、糖尿病肾病组(DN)和对照组以及不同尿蛋白排泄率(UAER)组患者血清中CytC、t-Hcy、BNP、hs-CRP、β2-MG水平并收集其他危险因素资料。结果:DN组中Scr、UAER、CytC、t-Hcy、BNP、hs-CRP、β2-MG、SBP、LDL-C、2hPG水平显著高于单纯糖尿病组(NDN)和对照组。多元逐步回归分析表明β2-MG、CytC、hs-CRP、tHcy、BNP是影响UAER的重要因素。UAER、β2-MG、tHcy、CytC、hs-CRP、BNP等指标在DN早期肾病时即有明显变化,并且随着病情加重各因子水平不断升高。结论:血CytC、t-Hcy、BNP、hs-CRP、β2-MG是早期诊断老年DN和评价预后的敏感指标。
Objective: To investigate the effects of CytC, t-Hcy, BNP, hs-CRP, β2-microglobulin (β2-MG) And elderly type 2 diabetic nephropathy (DN). Methods: The levels of CytC, t-Hcy, BNP, hs-CRP and β2-MG in serum of patients with type 2 diabetes mellitus (DNN), diabetic nephropathy (DN) and control group and different urinary protein excretion rate (UAER) And collect other risk factors information. Results: The levels of Scr, UAER, CytC, t-Hcy, BNP, hs-CRP, β2-MG, SBP, LDL-C and 2hPG in DN group were significantly higher than those in NDN group and control group. Multivariate stepwise regression analysis showed that β2-MG, CytC, hs-CRP, tHcy, BNP are important factors affecting UAER. The indexes of UAER, β2-MG, tHcy, CytC, hs-CRP and BNP have obvious changes in the early stage of DN, and the level of each factor increases with the exacerbation. Conclusion: CytC, t-Hcy, BNP, hs-CRP and β2-MG are the sensitive indicators for early diagnosis of elderly DN and evaluation of prognosis.