目的观察女性高血压患者血清G蛋白耦联雌激素受体(GPER)水平的变化。方法采用1∶1配对病例对照研究,以2015年7-11月在苏州大学附属第二医院体检的女性为研究对象,调查高血压者和正常血压者共502对,测量血压、身高、体质量和腰围,问卷收集吸烟、饮酒、家族史等情况,检测血脂、血糖、尿酸和血清GPER等指标。采用单因素和多因素条件Logistic回归方法,进行血清GPER水平与女性高血压的关联性分析。结果高血压组的血清GPER水平低于正常血压组[125.08(92.39,169.56)比143.61(94.76,207.82)ng/L,P<0.05]。条件Logistic回归模型显示,调整多因素后,血清GPER水平和高血压存在关联性(OR=0.800,95%CI 0.696,0.919)。在未绝经女性中,血清GPER水平与高血压没有关联(P>0.05);在绝经女性中,与最低四分位者相比,血清GPER水平处于最高四分位者患高血压的危险性是0.474倍(95%CI 0.287,0.785),且随血清GPER水平的升高,患高血压的危险性下降(趋势检验P<0.05)。结论在绝经女性人群中血清GPER水平与高血压有关联。 Objective To observe the changes of serum G protein coupled with estrogen receptor (GPER) in female patients with hypertension. Methods A 1: 1 matched case-control study was conducted to investigate the prevalence rate of hypertension and normal blood pressure in 502 females from July to November 2015 in the Second Affiliated Hospital of Soochow University. Blood pressure, height, weight And waist circumference, questionnaire collection of smoking, drinking, family history and other conditions, detection of blood lipids, blood glucose, uric acid and serum GPER and other indicators. Univariate and multivariate logistic regression analysis was used to analyze the correlation between serum GPER and female hypertension. Results The serum level of GPER in hypertension group was lower than that in normotensive group [125.08 (92.39,169.56) vs 143.61 (94.76, 207.82) ng / L, P <0.05]. Conditional Logistic regression model showed that there was a correlation between serum GPER and hypertension after adjusting for multiple factors (OR = 0.800, 95% CI 0.696, 0.919). In non-menopausal women, there was no association between serum GPER levels and hypertension (P> 0.05). In menopausal women, the highest quintile serum cholesterol level compared with the lowest quartile was 0.474 fold (95% CI 0.287,0.785), and with the rise of serum GPER, the risk of suffering from hypertension decreased (trend test P <0.05). Conclusions Serum GPER levels are associated with hypertension in postmenopausal women.