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目的 :比较甲磺酸托烷司琼和盐酸托烷司琼 (商品名 :欧必亭 )控制由顺铂、多柔比星 (阿霉素 )化疗所致胃肠道反应的疗效和不良反应。方法 :采用开放、随机自身交叉对照方法。 39例接受含顺铂和 (或 )多柔比星化疗的肿瘤患者随机进入AB ,BA组。AB组第 1周期化疗止吐给予甲磺酸托烷司琼 ,第 2周期给予盐酸托烷司琼 ;BA组则相反。同一患者接受的第 1 ,2周期化疗方案完全相同。结果 :入组患者中 ,9例未按试验要求完成观察 ,故可评价疗效患者 30例。A周期可评价不良反应 35例 ,B周期 36例。全组患者用甲磺酸托烷司琼后对食欲的影响 ,对恶心和呕吐的控制与盐酸托烷司琼相似 ,两组间差异无显著性 (均为P >0 .0 5 )。与两药可能相关的不良反应为轻度 ,均可耐受。结论 :国产甲磺酸托烷司琼治疗顺铂、多柔比星化疗所致胃肠道反应的疗效和不良反应与进口药盐酸托烷司琼相似
OBJECTIVE: To compare the efficacy and side effects of tropisetron mesylate and tropisetron hydrochloride (trade name: Euriputin) in the control of gastrointestinal reactions induced by cisplatin and doxorubicin (doxorubicin) chemotherapy. Methods: The open, random self-cross-control method. Thirty-nine patients with tumors who received cisplatin and / or doxorubicin chemotherapy were randomized into AB and BA groups. In the first cycle of AB group, antiemetic was given tropisetron mesylate, the second cycle was given tropisetron hydrochloride; BA group was the opposite. The same patients receive the first and second cycles of chemotherapy exactly the same. Results: In the group of patients, 9 cases did not complete the test required by the test, it can evaluate the efficacy of 30 patients. A cycle can be evaluated in 35 cases of adverse reactions, B cycle in 36 cases. All patients with tropisetron mesylate on appetite, nausea and vomiting control and tropisetron hydrochloride similar, no significant difference between the two groups (all P> 0.05). Adverse reactions that may be associated with both drugs are mild and tolerable. CONCLUSION: The efficacy and adverse reactions of domestic tovaracetasone mesylate in the treatment of gastrointestinal reactions induced by cisplatin and doxorubicine are similar to those of imported tropisetron