论文部分内容阅读
铜绿假单胞菌接种于含次抑菌浓度的哌拉西林和阿米卡星的营养肉汤中，葡萄球菌接种于次抑菌浓度的氧氟沙星和环丙沙星的营养肉汤中，经传代培养可获得相对应的耐药菌株。哌拉西林诱导耐药的铜绿假单胞菌对头孢他啶亦耐药，但对阿米卡星、环丙沙星、亚胺培南／西司他丁不耐药；阿米卡星诱导耐药的铜绿假单胞菌对哌拉西林亦耐药，但对头孢他啶、环丙沙星、亚胺培南／西司他丁没有交叉耐药；氧氟沙星或环丙沙星诱导耐药的葡萄球菌对氟喹诺酮类药物都有交叉耐药，但对苯唑西林、阿米卡星、亚胺培南／西司他丁没有显著的交叉耐药性
Pseudomonas aeruginosa was inoculated into the nutrient broth containing piperacillin and amikacin with the second bacteriostatic concentration, and the staphylococci were inoculated into the nutrient broth of ofloxacin and ciprofloxacin with the second bacteriostatic concentration , The subculture can get the corresponding resistant strains. Piperacillin-induced resistance to P. aeruginosa was also resistant to ceftazidime but not to amikacin, ciprofloxacin, imipenem / cilastatin, and amikacin-induced resistance Of Pseudomonas aeruginosa were also resistant to piperacillin but not to ceftazidime, ciprofloxacin, imipenem / cilastatin, and ofloxacin or ciprofloxacin-induced resistance Staphylococci are cross-resistant to fluoroquinolones, but have no significant cross-resistance to oxacillin, amikacin, imipenem / cilastatin