程序性死亡受体-1(PD-1)是用消减杂交技术从发生程序性死亡的T细胞株中分离得到的一种跨膜蛋白,是一种负向协同刺激分子。PD-1是活化T细胞表面的一种抑制性受体,与病毒特异性CD8+T细胞的功能耗竭有着密切关系。在乙型肝炎病毒和丙型肝炎病毒慢性感染过程中PD-1表达增强,阻断PD-1信号通路可以使耗竭的CD8+T细胞恢复免疫效应功能,有助于病毒清除,本文就PD-1与病毒性肝炎的关系及其在治疗中应用的前景作一综述。 Programmed death receptor-1 (PD-1) is a transmembrane protein isolated from a programmed cell death T cell line by subtractive hybridization and is a negative co-stimulatory molecule. PD-1 is an inhibitory receptor on the surface of activated T cells and is closely related to the functional depletion of virus-specific CD8 + T cells. PD-1 expression is enhanced during the chronic infection of Hepatitis B virus and Hepatitis C virus. Blocking the PD-1 signaling pathway can restore the immune effector function of depleted CD8 + T cells and contribute to virus clearance. In this paper, PD- 1 and viral hepatitis and its application in the treatment of the prospects are reviewed.