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[目的]了解和评价乙肝疫苗预防接种效果,为更好地制定实施乙肝免疫预防策略。[方法]对1995～2009年临沂市新生儿乙肝疫苗接种和3～18岁人群血清HBsAg检测资料进行分析。[结果]新生儿乙肝疫苗报告接种率,1995年为89.45%,2000年为82.53%,其他年份为92.07%～99.96%;首针及时接种率,2000～2009年分别为82.53%、89.85%、90.08%、99.19%、99.89%、98.48%、93.05%、98.37%、98.45%、98.43%。3～18岁儿童HBsAg阳性率,1995年为7.93%,2004年为3.61%,2009年为2.27%(P<0.01);3次调查中均有随着年龄的增长而增高的趋势(P<0.01)。3～14岁儿童抗-HBs阳性率,1995年为23.64%,2009年为69.60%(P<0.01)。[结论]临沂市新生儿乙肝疫苗接种率已经达到99%以上,首针及时接种率达到98%以上;3～18岁人群HBsAg阳性率逐渐降低,抗-HBs阳性率逐渐升高。
[Objective] To understand and evaluate the effect of hepatitis B vaccination in order to better formulate and implement hepatitis B immunization strategy. [Methods] The data of HBsAg detection in newborns with hepatitis B in Linyi from 1995 to 2009 and in the population of 3 ~ 18 years old were analyzed. [Results] The coverage rate of neonatal hepatitis B vaccine was 89.45% in 1995, 82.53% in 2000 and 92.07% -99.96% in other years. The first-dose timely vaccination rate was 82.53% and 89.85% respectively from 2000 to 2009, 90.08%, 99.19%, 99.89%, 98.48%, 93.05%, 98.37%, 98.45%, 98.43%. The positive rate of HBsAg in children aged 3-18 years was 7.393% in 1995, 3.61% in 2004 and 2.27% in 2009 (P <0.01). There was a trend of increasing HBsAg in all 3 surveys (P < 0.01). The positive rate of anti-HBs in children aged 3-14 years was 23.64% in 1995 and 69.60% in 2009 (P <0.01). [Conclusion] The vaccination rate of hepatitis B vaccine of newborns reached more than 99% in Linyi City, and the first-dose timely vaccination rate reached over 98%. The positive rate of HBsAg in 3-18-year-old population gradually decreased and the positive rate of anti-HBs gradually increased.