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在探讨19种生药对HeLa细胞耐受抗癌药的影响时发现,部分生药可以改变抗癌药的感受性。这种变化可能与MDR1/p-糖蛋白有关。本次用MDR1高表达的耐受紫杉醇(TXL)的HeLa细胞(HeLa/TXL)探讨了生药改善抗癌药耐受的作用。方法:①用含有10%FBS及20nM TXL的DMEM传代培养HeLa/TXL细胞。
When examining the effects of 19 crude drugs on HeLa cells tolerant to anticancer drugs, it was found that some crude drugs can change the sensitivity of anticancer drugs. This change may be related to MDR1/p-glycoprotein. The HeLa cells (HeLa/TXL) tolerated by paclitaxel (TXL) highly expressed in MDR1 were used to investigate the effects of crude drugs in improving the tolerance of anticancer drugs. Methods: 1 HeLa/TXL cells were subcultured with DMEM containing 10% FBS and 20 nM TXL.