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目的:研究子宫内膜异位症(EM)患者手术前后血清中CA125的水平。方法:选择手术治疗子宫内膜异位症患者62例,测定手术前后患者血清CA125水平,并与非EM组58例患者CA125水平进行比较。结果:随着患者EM分期的升级,CA125值呈上升趋势,两者之间存在很好的线性关系(r2=0.886,P<0.01),且EM患者的术前CA125值较非EM高(P<0.01)。第Ⅰ、第Ⅱ、第Ⅲ期术后CA125值较术前有显著下降(第Ⅰ、Ⅱ期,P<0.01;第Ⅲ期P<0.05);而且各期EM患者之间的CA125存在明显的统计学差异(P<0.01);各时期患者术前的CA125值之间呈显著正相关(r=0.726 4,P<0.01)。结论:CA125与EM的发生、发展有关,且随着病情进展而升高,对EM诊断具有十分重要的意义。
Objective: To study the serum levels of CA125 in patients with endometriosis (EM) before and after surgery. Methods: Sixty-two patients with endometriosis were selected for surgery. Serum CA125 levels were measured before and after surgery. The levels of CA125 in 58 patients with non-EM were compared. Results: With the escalation of EM staging, the CA125 value showed an upward trend with a good linear relationship (r2 = 0.886, P <0.01), and the preoperative CA125 value in patients with EM was higher than that in non-EM <0.01). There was a significant decrease of CA125 in stage Ⅰ, Ⅱ, Ⅲ after operation (Ⅰ, Ⅱ, P <0.01; Ⅲ) (P <0.05) (P <0.01). There was a significant positive correlation between preoperative CA125 values at each time point (r = 0.726 4, P <0.01). Conclusion: CA125 is associated with the occurrence and development of EM, and with the progression of the disease, it is of great significance for the diagnosis of EM.