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病原菌从肠腔进入肠系膜淋巴结(MLN)及其他肠外器官和部位的过程称为细菌易位。本文目在研究实验性门脉高压急性和慢性阶段时细菌易位的情况。 材料和方法:第一实验为13只大鼠经门静脉部分结扎造成急性门脉高压,使门腔分流极少,对照组为13只作腹腔假手术及10只作下腔静脉狭窄手术,均于术后2天杀死。第二实验将15只门脉部分结扎大鼠在术后10～20天(平均15天)处死,为慢性门脉高压模型,均有明显门腔静脉分流,对照组11只作腹腔假手术。动物处死后对MLN、血、肝、脾标本分别作细菌培养,对远段回肠作组织学检查。
The process by which pathogenic bacteria enter the mesenteric lymph nodes (MLNs) and other extraintestinal organs and sites from the intestine is called bacterial translocation. This article aims to investigate the bacterial translocation in experimental acute and chronic portal hypertension. MATERIALS AND METHODS: In the first experiment, 13 rats were subjected to partial portal vein ligation to cause acute portal hypertension, resulting in minimal portal shunting. The control group consisted of 13 rabbits undergoing peritoneal sham operation and 10 rabbits undergoing IVC stenosis. 2 days after surgery to kill. In the second experiment, 15 rats with partial portal vein ligation were sacrificed 10 to 20 days after operation (15 days on average). They were all models of chronic portal hypertension with significant portal venous shunts. The control group, 11, were treated with peritoneal surgeries. Animals were sacrificed on the MLN, blood, liver and spleen specimens were cultured for histological examination of distal ileum.