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目的探讨外环境因素在隔膜型布-加综合征(Budd鄄Chiarisyndrome,B鄄CS)发病中的作用。方法在已掌握的山东省菏泽市700余份B鄄CS病历的临床资料中选择128例隔膜型患者调查其生活环境,同时对外环境饮用水多元素进行检测和分析。结果128例患者饮用水金属元素均在正常值范围内;水碘测定,有98.44%的患者饮用水含碘在150μg/L以上,属于高碘地区,其中150￣300μg/L的占27.35%,300μg/L以上的占71.09%;水氟测定,饮用水含氟在正常范围的占1.56%,在轻病区范围(1.0￣2.0mg/L)的占75.00%,在中等病区范围(2.0￣4.0mg/L)的占23.44%。结论B鄄CS的发生可能与外环境饮用水高碘和高氟密切相关,碘和氟在B鄄CS的发病机制中的作用是值得进行深入研究的课题。
Objective To investigate the role of external environmental factors in the pathogenesis of Budd-Chiari syndrome (B-CS). Methods Seventy-two cases of septal patients were selected from clinical data of over 700 B-CS cases in Heze city of Shandong province to investigate the living environment and to detect and analyze the multi-elements of drinking water in the external environment. Results The drinking water of 128 patients were all within the normal range. In the measurement of water iodine, 98.44% of the drinking water contained iodine above 150μg / L, belonging to high iodine area, of which, 27.35% were 150 ~ 300μg / L, 300μg / L or more accounted for 71.09%; Determination of water fluoride, drinking water fluorine in the normal range of 1.56%, in the light area (1.0 ~ 2.0mg / L) accounted for 75.00%, in the medium ward range ~ 4.0mg / L) accounted for 23.44%. Conclusions The occurrence of B-CS may be closely related to the high iodine and high fluoride content of drinking water in the external environment. The role of iodine and fluorine in the pathogenesis of B-CS is worth further study.