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肿瘤干细胞是指肿瘤中具有自我更新能力并能产生异质性肿瘤细胞的细胞,目前越来越多的研究表明,肿瘤是一种干细胞疾病。最近研究发现,前列腺癌中亦存在具有干细胞特性的肿瘤细胞。肿瘤干细胞的研究进展为进一步研究肿瘤细胞的生物学特性开辟了新的方向,它突破了以往把肿瘤视为均一、整体的研究思路,对于前列腺癌靶向治疗具有重要意义。现就肿瘤干细胞的基本内容、分离方法以及前列腺癌肿瘤干细胞的特性和目前研究存在的问题予以综述。
Tumor stem cells refer to cells that have self-renewal ability and produce heterogeneous tumor cells in tumors, and more and more studies show that tumor is a kind of stem cell disease. Recent studies have found that prostate cancer cells also have the characteristics of stem cells. The research progress of tumor stem cells has opened up a new direction for further study on the biological characteristics of tumor cells. It broke through the idea of treating tumor as a uniform and holistic research in the past, which is of great significance for the targeted therapy of prostate cancer. Now on the basic content of cancer stem cells, isolation methods and characteristics of prostate cancer stem cells and the current research problems are reviewed.