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为了探讨磷酸二酯酶抑制剂西地那非在脑动脉血管活性效应中K+和Ca2+(离子)流的作用,Salom等做了一项相关研究,研究者使用离体兔子的脑基底动脉来评价西地那非诱导的血管扩张细胞外K+升高的效应,并且研究西地那非对K+、Ca2+离子膜通道选择性递质的药理作用。信使和蛋白的水平用
In order to investigate the role of the phosphodiesterase inhibitor sildenafil in the effects of K + and Ca2 + currents on cerebral arterial vasomotor activity, Salom et al. Performed a study using in vitro rabbit cerebral basilar artery The effect of sildenafil on the increase of extracellular K + in vasodilator cells and the pharmacological effects of sildenafil on the selective neurotransmitters of K + and Ca2 + ion channels were also investigated. Messenger and protein levels used