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目的探讨研究吲达帕胺与双氢克尿噻治疗高血压的临床疗效及安全性。方法选取神池县中医院2011年1月—2014年1月收治的符合要求的高血压患者200例,采用随机数字表法分为观察组和对照组,每组100例。对照组患者给予双氢克尿噻治疗,观察组患者给予吲达帕胺治疗。比较两组患者治疗前后血压、实验室检查指标及不良反应发生情况。结果治疗前两组患者收缩压及舒张压比较,差异无统计学意义(P>0.05);治疗后两组患者舒张压与收缩压比较,差异无统计学意义(P>0.05)。治疗前两组患者实验室检查指标比较,差异无统计学意义(P>0.05);治疗后对照组患者血钾低于观察组,差异有统计学意义(P<0.05)。观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论吲达帕胺治疗高血压的临床疗效确切,且不良反应少。
Objective To study the clinical efficacy and safety of indapamide and hydrochlorothiazide in the treatment of hypertension. Methods 200 cases of hypertensive patients admitted from January 2011 to January 2014 in Shenchi County Chinese Medicine Hospital were selected and divided into observation group and control group with 100 cases in each group. Patients in the control group were treated with hydrochlorothiazide, and patients in the observation group were given indapamide. Before and after treatment, blood pressure, laboratory tests and adverse reactions were compared between the two groups. Results There was no significant difference in systolic pressure and diastolic pressure between the two groups before treatment (P> 0.05). There was no significant difference in diastolic pressure and systolic pressure between the two groups after treatment (P> 0.05). There was no significant difference between the two groups before the treatment (P> 0.05). After treatment, the serum potassium of the control group was lower than that of the observation group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group, the difference was statistically significant (P <0.05). Conclusion Indapamide is effective in treating hypertension with less adverse reactions.