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目的 比较三苯氧胺与雌激素对骨代谢的影响 ,及两者与氟化物配伍后是否产生协同效果。方法 将 142只 6月龄雌性SD大鼠行去势手术或假手术后随机分为 7组 (每组 19～ 2 1只 ) :(1)假手术组 ;(2 )去势组 ;(3)雌激素组 ;(4 )氟化物组 ;(5 )雌激素 +氟化物组 ;(6 )三苯氧胺组 ;(7)三苯氧胺 +氟化物组。治疗 12个月 ,行骨密度、腰椎骨组织形态计量学参数 (不脱钙骨切片 )、右股骨中段三点弯曲试验观察 ,并行子宫病理及血脂检查。结果 (1)术后 12个月时 ,全身骨密度去势组为2 79mg/cm2 、治疗组为 2 86～ 2 98mg/cm2 ,腰椎骨密度分别为 2 32mg/cm2 、2 5 1～ 2 6 6mg/cm2 (P均<0 0 5 ) ;股骨中段骨密度 ,雌激素组 2 16mg/cm2 ,明显高于三苯氧胺组 195mg/cm2 (P <0 0 5 ) ;配伍治疗组与单药治疗组无明显差异 (P >0 0 5 )。 (2 )术后 4个月 ,两个配伍治疗组最大载荷 (均为 145牛顿 )与去势组 [(118± 2 4)牛顿 ]有显著差异 (P <0 0 5 ) ;术后 12个月各治疗组最大载荷为 132～ 15 5牛顿 ,均明显高于去势组 (10 8± 13)牛顿 (P <0 0 5 ) ,雌激素组最大载荷、弹性载荷均明显高于三苯氧胺组 (P <0 0 5 )。 (3)各组骨组织形态计量学检查未发现骨矿化不良现象。结论 雌激素在维持骨量、骨强度方面优于三苯?
Objective To compare the effect of tamoxifen and estrogen on bone metabolism, and whether synergistic effect of the two with fluoride was obtained. Methods 142 male 6-month-old female SD rats were randomly divided into 7 groups (19 ~ 21 in each group) undergoing castration or sham operation: (1) Sham operation group; (2) ) Estrogen group (4) fluoride group (5) estrogen + fluoride group (6) tamoxifen group (7) tamoxifen + fluoride group. After 12 months of treatment, bone mineral density, lumbar bone histomorphometry (non-decalcified bone slices) and right femur three-point bending test were observed, and pathological examination of uterus and blood lipids were performed. Results (1) At 12 months after operation, total body mineral density castration group was 2 79 mg / cm2, treatment group was 2 86-2 98 mg / cm2, lumbar spine BMD was 2 32 mg / cm2, and 2 51-2 6 (P <0.05). The middle femur BMD, estrogen group 2 16mg / cm2, was significantly higher than the tamoxifen group 195mg / cm2 (P <0 05); compatibility treatment group and monotherapy group no Significant difference (P> 0 0 5). (2) There was a significant difference (P <0 05) between the maximum load of the two compatibility treatment groups (both 145 Newtons) and the castration group [(118 ± 24) The monthly maximum load of each treatment group was 132-15 5 Newton, which was significantly higher than that of castrated group (108 ± 13) Newtons (P <0.05). The maximal load and elastic load of estrogen group were significantly higher than that of tamoxifen group P <0 0 5). (3) Bone mineralosis was not found in all groups. Conclusion Estrogen is superior to triphenylbenzene in maintaining bone mass and bone strength.