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目的通过观察血清α-羟丁酸脱氢酶(α-HBDH)的变化,探讨慢性心力衰竭与α- HBDH之间的关系。方法心衰组30例均为住院的慢性心力衰竭患者,均除外合并急性心肌梗死。对照组28例,均除外心脏病。心衰组按NYHA心功能分级:Ⅱ级7例,Ⅲ级10例,Ⅳ级13例。测定血清α-HBDH数值,正常值72-182 U/L,统计学处理,计算各组α-HBDH的平均值,用t检验。结果对照组与心衰组的α-HBDH水平分别为(152．6±37．7)U／L、(221．4±68．9)U／L(P< 0．01),心功能Ⅱ、Ⅲ级与Ⅳ级的α-HBDH水平分别为(189．6±27．4)U／L、(276．0±63．5)U／L(P< 0．01),差异均有统计学意义。结论慢性心力衰竭患者血中α-HBDH水平升高,且随心衰程度的加重而增加。
Objective To explore the relationship between chronic heart failure and α-HBDH by observing the changes of serum α-hydroxybutyrate dehydrogenase (α-HBDH). Methods 30 cases of heart failure patients were hospitalized patients with chronic heart failure, except with acute myocardial infarction. Control group, 28 cases, except for heart disease. According to NYHA functional classification, heart failure group was classified as grade Ⅱ in 7 cases, grade Ⅲ in 10 cases and grade Ⅳ in 13 cases. Determination of serum a-HBDH values, the normal 72-182 U / L, statistical analysis, calculated the average of α-HBDH in each group, using t test. Results The levels of α-HBDH in control group and HF group were (152.6 ± 37.7) U / L, (221.4 ± 68.9) U / L, P <0.01) (189.6 ± 27.4) U / L and (276.0 ± 63.5) U / L, respectively (P <0.01), the differences were statistically significant Significance of learning. Conclusion The level of α-HBDH in the blood of patients with chronic heart failure is increased, and increases with the severity of heart failure.