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目的探讨广泛性临床下痫样放电的精神发育迟缓患儿抗癫痫治疗的效果。方法自2005年1月1日至2006年6月30日在我科确诊为广泛性临床下痫样放电的精神发育迟缓患儿50例,随机分成试验组和对照组,全部患儿接受脑营养药物、康复训练治疗,试验组添加丙戊酸钠,分别评估患儿在实验开始时和6个月后的认知发育水平,并检查自然睡眠脑电图。结果47例完成了本研究,于6个月时试验组脑电图改善显著较对照组满意(P<0.001),认知指数显著高于对照组(P<0.05)。结论对于广泛性临床下痫样放电的精神发育迟缓患儿,在康复训练的同时经积极抗癫痫治疗后,脑电图中癫痫样放电得到抑制,认知功能发育显著加快。
Objective To investigate the effect of antiepileptic therapy on children with mental retardation in generalized clinical epileptiform discharges. Methods From January 1, 2005 to June 30, 2006, 50 children with mental retardation who were diagnosed as generalized clinical epileptiform discharges in our department were randomly divided into experimental group and control group. All children received brain nutrition Drugs, rehabilitation training treatment, the experimental group added sodium valproate, children were assessed at the beginning of the experiment and 6 months after the cognitive development, and check the natural sleep EEG. Results The study was completed in 47 cases. At 6 months, the EEG improvement in the experimental group was significantly better than that in the control group (P <0.001), and the cognitive index was significantly higher than that in the control group (P <0.05). Conclusions For children with mental retardation under generalized clinical epileptiform discharge, epileptiform discharge in EEG is inhibited and cognitive function development is accelerated significantly after rehabilitation training and active antiepileptic treatment.