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曾在雄性啮齿动物实验中发现乙胺嘧啶(PYR)、2,4二氨基嘧啶(2,4-DAP)有可逆性抗生育的效应,目前这一发现在大鼠研究中得到证实。同时,对另一种抗叶酸药氨甲喋呤(MTX)也进行了研究,提示即使MTX在大剂量时也无抗生育作用。由组织分布研究显示MTX与PYR的差异在于前者为亲水性,后者为亲脂性。通过抑制二氢叶酸还原酶
In male rodent experiments, pyrimethamine (PYR) and 2,4-diaminopyrimidine (2,4-DAP) were found to have reversible anti-fertility effects, a finding that is currently being demonstrated in rat studies. In the meantime, another antifolate, methotrexate (MTX), was also studied, suggesting that even MTX has no anti-fertility effects at high doses. Tissue distribution studies have shown that the difference between MTX and PYR is that the former is hydrophilic and the latter is lipophilic. By inhibiting dihydrofolate reductase