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血管平滑肌和内皮细胞的Ｃａ２＋内流机制不同，前者是兴奋性细胞，Ｃａ２＋内流通过电压依赖性（ＶＤＣ）和非电压依赖性Ｃａ２＋通道；后者是非兴奋性细胞，Ｃａ２＋内流主要通过非ＶＤＣ途径。Ｃｌ－通道参与了这两种细胞的Ｃａ２＋调控，平滑肌细胞Ｃｌ－通道开放导致细胞膜去极化，促进ＶＤＣ开放，Ｃａ２＋内流增加；而内皮细胞Ｃｌ－通道开放导致细胞膜超极化，使Ｃａ２＋进入细胞内的电化学趋势增加，胞外Ｃａ２＋经非ＶＤＣ途径内流增加。目前对血管平滑肌和内皮细胞Ｃｌ－通道的分型、特性和功能还不清楚。
The mechanisms of Ca2 + influx in vascular smooth muscle and endothelial cells are different. The former is excitatory cells. Ca2 + influxes through voltage-dependent (VDC) and non-voltage-dependent Ca2 + channels. The latter is non-excitatory cells. Ca2 + way. Cl- channels are involved in the regulation of Ca2 + in both cells. The opening of Cl- channels in smooth muscle cells leads to the depolarization of cell membrane, promoting the opening of VDC and the increase of Ca2 + influx. The opening of Cl- channel in endothelial cells leads to hyperpolarization of cell membrane, The intracellular electrochemical trend increased, extracellular Ca2 + increased by non-VDC pathway influx. Currently, the classification, characterization and function of Cl-channels in vascular smooth muscle and endothelial cells are unclear.