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AIM:To investigate if increased dietary fiber,in terms of kiwifruit,is effective in Chinese constipated patients. METHODS:33 constipated patients and 20 healthy volunteers were recruited for a 4-wk treatment of kiwi fruit twice daily.Response during wk 1-4 was defined as an increase in complete spontaneous bowl,motion (CSBM)≥1/wk.Secondary efficacy included response during wk 1-4,individual symptoms and scores of bowel habits and constipation.Responses were compared with the baseline run-in period.Colonic transit time and anorectal manometry were performed before and after treatment. RESULTS:Responder rate was 54.5% in the constipated group.The mean CSBM increased after treatment (2.2±2.6 vs 4.4±4.6,P=0.013).There was also improvement in the scores for bothersomeness of constipation(P=0.02),and satisfaction of bowel habit (P=0.001),and decreased in days of laxative used(P= 0.003).There was also improvement in transit time(P= 0.003)and rectal sensation(P<0.05).However,there was no change in the bowel symptoms or anorectal physiology in the healthy subjects. CONCLUSION:Increasing dietary fiber intake is effective in relieving chronic constipation in Chinese population.
METHODS: 33 patients were recruited for a 4-wk treatment of kiwi fruit twice daily. Response to wk 1-4 was defined as an increase in complete spontaneous bowl, motion (CSBM) ≧ 1 / wk. Secondary efficacy included response during wk 1-4, individual symptoms and scores of bowel habits and constipation. Responses were compared with the baseline run-in period. Colonic transit time and anorectal manometry were performed before and after treatment. RESULTS: Responder rate was 54.5% in the constipated group. The mean CSBM increased after treatment (2.2 ± 2.6 vs. 4.4 ± 4.6, P = 0.013). There was also improvement in the scores for bothersomeness of constipation (P = 0.02), and satisfaction of bowel habit (P = 0.001), and decreased in days of laxative used (P = 0.003). There was also improvement in transit time sensation (P <0.05) .However, there was no c hange in the bowel symptoms or anorectal physiology in the healthy subjects. CONCLUSION: Increasing dietary fiber intake is effective in relieving chronic constipation in Chinese population.