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氮芥局部应用始于匈牙利(1956)和美国(1959),此后这种治疗方法的优点逐步被确认.近年的资料使人能更好地了解氮芥应用的配制方法和副作用,并由于长期的应用而得以制订出较好的治疗方案.局部应用氮芥的配制方法常规的配制方法是将氮芥10mg溶解于普通水50ml中,配成0.02%水溶液,为了克服水溶液于治疗后引起局部皮肤干燥,可加入甘油或植物油2ml.本制品保存在室温中一个月失去50%活性,而在冰箱内贮藏8个月仍可保持100%活性.1977年Porres倡用氮芥软膏,在配制时需用沉淀法去除分子中含氯部分,具体步骤:将氮芥90mg溶于纯酒精15ml过滤,在室温下将过滤液混入凡士林450g中.软膏的
The topical application of nitrogen mustard started in Hungary (1956) and the United States (1959), after which the advantages of this treatment method were gradually confirmed. Recent data has enabled people to better understand the preparation methods and side effects of nitrogen mustard application, and due to long-term Application to be able to develop a better treatment program. Topical application of nitrogen mustard preparation method The conventional preparation method is to dissolve nitrogen mustard 10mg in 50ml of ordinary water, dubbed 0.02% aqueous solution, in order to overcome the aqueous solution caused by local dry skin after treatment , Can add glycerin or vegetable oil 2ml. This product is stored at room temperature lose 50% activity a month, but still can maintain 100% activity in the refrigerator for 8 months. In 1977 Porres advocated using nitrogen mustard ointment, used in the preparation Precipitate method to remove the chlorine content of the molecule, the specific steps: the nitrogen mustard 90mg dissolved in 15ml of pure alcohol, filtered at room temperature into the vaseline 450g. Ointment of